Journal of Surgical Education
Volume 66, Issue 3 , Pages 163-167 , May 2009

Diagnosis and Surgical Management of Spontaneous Hepatic Rupture Associated with HELLP Syndrome

  • Theodoros Pavlis, MD

      Affiliations

    • Intensive Care Unit, “Mitera” Hospital of Athens, Greece
    • ,
  • Stavros Aloizos, MD

      Affiliations

    • Intensive Care Unit, “Mitera” Hospital of Athens, Greece
    • ,
  • Paraskevi Aravosita, MD

      Affiliations

    • Intensive Care Unit, “Mitera” Hospital of Athens, Greece
    • ,
  • Christina Mystakelli, MD

      Affiliations

    • Intensive Care Unit, “Mitera” Hospital of Athens, Greece
    • ,
  • Dimitra Petrochilou, MD

      Affiliations

    • Second Surgical Department, Athens, Greece
    • ,
  • Nikitas Dimopoulos, MD

      Affiliations

    • Second Surgical Department, Athens, Greece
    • ,
  • Stavros Gourgiotis, MD

      Affiliations

    • Second Surgical Department, Athens, Greece
    • Corresponding Author InformationCorrespondence: Inquiries to Stavros Gourgiotis, MD, PhD, 41 Zakinthinou Street, 15669 Papagou, Athens, Greece; fax: 00 30 21 06 52 5802

References 

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  3. Hulstein JJ, van Runnard Heimel PJ, Franx A, et al. Acute activation of the endothelium results in increased levels of active von Willebrand factor in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. J Thromb Haemost. 2006;4:2569–2575
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  5. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing?. Am J Obstet Gynecol. 1990;162:311–316
  6. Mihu D, Costin N, Mihu CM, Seicean A, Ciortea R. HELLP syndrome—A multisystemic disorder. J Gastrointestin Liver Dis. 2007;16:419–424
  7. Norwitz ER, Hsu CD, Repke JT. Acute complications of preeclampsia. Clin Obstet Gynecol. 2002;45:308–329
  8. Stevenson JT, Graham DJ. Hepatic hemorrhage and the HELLP syndrome: A surgeon's perspective. Am Surg. 1995;61:756–760
  9. Rinehart BK, Terrone DA, Magann EF, et al. Preeclampsia-associated hepatic hemorrhage and rupture: mode of management related to maternal and perinatal outcome. Obstet Gynecol Surv. 1999;54:196–202
  10. Wicke C, Pereira PL, Neeser E, et al. Subcapsular liver hematoma in HELLP syndrome: evaluation of diagnostic and therapeutic options (A unicenter study). Am J Obstet Gynecol. 2004;190:106–112
  11. Nunes JO, Turner MA, Fulcher AS. Abdominal imaging features of HELLP syndrome: a 10-year retrospective review. AJR Am J Roentgenol. 2005;185:1205–1210
  12. Neerhof MG, Zelman W, Sullivan T. Hepatic rupture in pregnancy. Obstet Gynecol Surv. 1989;44:407–409
  13. Araujo AJ, Leao MD, Nobrega MH, et al. Characteristics and treatment of hepatic rupture caused by HELLP syndrome. Am J Obstet Gynecol. 2006;195:129–133
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  18. Gilboa Y, Bardin R, Feldberg D, Bachar GN. Postpartum hepatic rupture and retroperitoneal hematoma associated with HELLP syndrome. Isr Med Assoc J. 2006;8:219–220
  19. Agatisa PK, Ness RB, Roberts JM, et al. Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk. Am J Physiol Heart Circ Physiol. 2004;286:1389–1393
  20. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683
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  23. King DR, de Moya MM, McKenney MG, Cohn SM. Modified rapid deployment hemostat terminates bleeding from hepatic rupture in third trimester. J Trauma. 2006;61:739–742
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  26. Hedner U, Erhardtsen E. Potential role for rFVIIa in transfusion medicine. Transfusion. 2002;42:114–124
  27. Hedner U, Erhardtsen E. Potential role of rFVIIa in transfusion medicine. Transfusion. 2002;42:114–124
  28. Vincent JL, Rossaint R, Riou B, et al. Recommendations on the use of factor VIIa as adjunctive treatment for massive bleeding—A European perspective. Crit Care. 2006;10:R120

PII: S1931-7204(09)00061-0

doi: 10.1016/j.jsurg.2009.04.001

Journal of Surgical Education
Volume 66, Issue 3 , Pages 163-167 , May 2009

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