Journal of Surgical Education
Volume 64, Issue 5 , Pages 273-277 , September 2007

Influence of Systemic Hypotension on Skeletal Muscle Ischemia-Reperfusion Injury After 4-Hour Tourniquet Application

  • David S. Kauvar, MD
    • ,
  • David G. Baer, PhD
    • ,
  • Thomas J. Walters, PhD

      Affiliations

    • Corresponding Author InformationCorrespondence: Inquiries to Thomas J. Walters, PhD, United States Army Institute of Surgical Research, 3400 Rawley E. Chambers Avenue, Fort Sam Houston, TX 78234; fax (210) 916-3877

References 

  1. Burkle FM, Newland C, Meister SJ, Blood CG. Emergency medicine in the Persian Gulf War—Part 3: Battlefield casualties. Ann Emerg Med. 1994;23:755–760
  2. Carey ME. Analysis of wounds incurred by U.S. Army Seventh Corps personnel treated in Corps hospitals during Operation Desert Storm, February 20 to March 10, 1991. J Trauma. 1996;40:S165–S169
  3. Mabry RL, Holcomb JB, Baker AM, et al. United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield. J Trauma. 2000;49:515–528discussion 528-519
  4. Maricevic A, Erceg M, Gekic K. Primary wound closure in war amputations of the limbs. Int Orthop. 1997;21:364–366
  5. Patel TH, Wenner KA, Price SA, Weber MA, Leveridge A, McAtee SJ. A U.S. Army Forward Surgical Team’s experience in Operation Iraqi Freedom. J Trauma. 2004;57:201–207
  6. Bellamy RF. The causes of death in conventional land warfare: implications for combat casualty care research. Mil Med. 1984;149:55–62
  7. Hardaway RM. Viet Nam wound analysis. J Trauma. 1978;18:635–643
  8. In:  Lounsbury DE,  Bellamy RF editor. Emergency War Surgery. 3rd ed.. Washington, DC: Borden Institute, Walter Reed Army Medical Center; 2004;
  9. Lakstein D, Blumenfeld A, Sokolov T, et al. Tourniquets for hemorrhage control on the battlefield: a 4-year accumulated experience. J Trauma. 2003;54:S221–S225
  10. Pedowitz RA. Tourniquet-induced neuromuscular injury (A recent review of rabbit and clinical experiments). Acta Orthop Scand. 1991;245:1–33
  11. Navein J, Coupland R, Dunn R. The tourniquet controversy. J Trauma. 2003;54:S219–S220
  12. Husum H, Gilbert M, Wisborg T, Pillgram-Larsen J. Prehospital tourniquets: there should be no controversy. J Trauma. 2004;56:214–215
  13. Amundson B, Bagge U. Hemorrhage and skeletal muscle microcirculation. Scand J Plast Reconstr Surg. 1982;19:16–17
  14. Powell RJ, Cronenwett JL, Gauthier AJ, Wagner RJ. Quantitating intestinal ischemia with nitroblue tetrazolium salts. J Surg Res. 1995;58:359–366
  15. Sternbergh WC, Adelman B. Skeletal muscle fiber type does not predict sensitivity to postischemic damage. J Surg Res. 1992;53:535–541
  16. Carvalho AJ, McKee NH, Green HJ. Metabolic and contractile responses of fast and slow twitch rat skeletal muscles to ischemia and reperfusion. Plast Reconstr Surg. 1997;99:163–171
  17. Chan RK, Austen WG, Ibrahim S, et al. Reperfusion injury to skeletal muscle affects primarily type II muscle fibers. J Surg Res. 2004;122:54–60
  18. Woitaske MD, McCarter RJ. Effects of fiber type on ischemia-reperfusion injury in mouse skeletal muscle. Plast Reconstr Surg. 1998;102:2052–2063
  19. Stamler JS, Meissner G. Physiology of nitric oxide in skeletal muscle. Physiol Rev. 2001;81:209–237
  20. Ji LL, Fu R, Mitchell EW. Glutathione and antioxidant enzymes in skeletal muscle: effects of fiber type and exercise intensity. J Appl Physiol. 1992;73:1854–1859
  21. Rubin BB, Romaschin A, Walker PM, Gute DC, Korthuis RJ. Mechanisms of postischemic injury in skeletal muscle: intervention strategies. J Appl Physiol. 1996;80:369–387
  22. Delp MD, Duan C. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle. J Appl Physiol. 1996;80:261–270
  23. Beyersdorf F, Sarai K, Mitrev Z, Eckel L, Ihnken K, Satter P. Studies of reperfusion injury in skeletal muscle: controlled limb reperfusion to reduce post-ischaemic syndrome. Cardiovasc Surg. 1993;1:330–336
  24. Ihnken K, Beyersdorf F, Winkelmann B, Unkelbach U. Reperfusion syndrome in skeletal muscle after prolonged incomplete ischemia: reduction by controlled limb reperfusion. Transplant Proc. 1995;27:2806–2808
  25. Mitrev Z, Beyersdorf F, Hallmann R, et al. Reperfusion injury in skeletal muscle: controlled limb reperfusion reduces local and systemic complications after prolonged ischaemia. Cardiovasc Surg. 1994;2:737–748
  26. Choudhury NA, Sakaguchi S, Koyano K, Matin AF, Muro H. Free radical injury in skeletal muscle ischemia and reperfusion. J Surg Res. 1991;51:392–398
  27. Sabido F, Milazzo VJ, Hobson RW, Duran WN. Skeletal muscle ischemia-reperfusion injury: a review of endothelial cell-leukocyte interactions. J Invest Surg. 1994;7:39–47

 Supported by the United States Army Medical Research and Materiel Command.

 The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or United States Government. The authors are employees of the U.S. Government, and this work was prepared as part of their official duties.

PII: S1931-7204(07)00169-9

doi: 10.1016/j.jsurg.2007.06.010

Journal of Surgical Education
Volume 64, Issue 5 , Pages 273-277 , September 2007

Article Tools

* Image Usage & Resolution