Journal of Surgical Education
Volume 64, Issue 1 , Pages 41-45 , January 2007

Comparison of Pleurodesis by Erythromycin, Talc, Doxycycline, and Diazepam in a Rabbit Model

Presented at CHEST 2002, San Diego, California. Presented at the Society of Air Force Clinical Surgeons, San Antonio, Texas, April 2003.

    Maj
  • Quintessa Miller, USAF, MC

      Affiliations

    • Department of Surgery, Wright State University School of Medicine, Dayton, Ohio
    • Corresponding Author InformationCorrespondence: Inquiries to Major Quintessa Miller, MD, Department of Surgery, Wright State University School of Medicine, Suite 7000, Miami Valley Hospital, One Wyoming Street, Dayton, OH 45409
    • ,
  • Carol Meschter, DVM

      Affiliations

    • Veterinary Pathology, Comparative Biosciences, Inc., Mountain View, California
    • ,
  • Terry Neumaster, MD

      Affiliations

    • General Surgery, Department of Veteran’s Affairs, Biloxi, Mississippi
    • , Lt Col
  • Jerry Pratt, USAF, MC

      Affiliations

    • Department of Cardiothoracic Surgery, Keesler Medical Center, Biloxi, Mississippi
    • , Lt Col
  • Michael Moulton, USAF, MC

      Affiliations

    • Department of Cardiothoracic Surgery, Keesler Medical Center, Biloxi, Mississippi
    • , Capt
  • Douglas Downey, USAF, MC

      Affiliations

    • Department of Surgery, Wright State University School of Medicine, Dayton, Ohio
    • , Maj
  • Joseph Harre, USAF, MC

      Affiliations

    • Armed Forces Radiobiology Research Institute, Bethesda, Maryland

References 

  1. Campos JR, Werebe EC, Vargas FS, Jatene FB, Light RW. Respiratory failure because of insufflated talc. Lancet. 1997;349:251–252
  2. Windsor PG, Como JA, Windsor KS. Sclerotherapy for malignant pleural effusions: alternatives to tetracycline. Southern Med J. 1994;8:709–713
  3. Mitchem RE, Herndon BL, Fiorella RM, Molteni A, Battie CN, Reisz GR. Pleurodesis by autologous blood, doxycycline, and talc in a rabbit model. Ann Thorac Surg. 1999;67:917–921
  4. Tang X, Cheng D. The value of erythromycin pleurodesis in the treatment of malignant pleural effusions. J West China Univ Med Sci. 1997;28:437–439
  5. Carvalho P, Knight LL, Olson RD, Crowley JJ, Hawk PA, Charan NB. Effects of erythromycin on the rabbit pleura: its potential role as a pleural sclerosant. Am J Respir Crit Care Med. 1995;151:1228–1232
  6. Mattson RH. Parental antiepileptic/anticonvulsant drugs. Neurology. 1996;46(suppl 1):S8–S13
  7. Hurewitz AN, Lidonicci K, Wu CL, Reim D, Zucker S. Histologic changes of doxycycline Pleurodesis in rabbits (Effect of concentration and pH). Chest. 1994;106:1241–1245
  8. Walker-Rennard PB, Vaughan LM, Sahn SA. Chemical pleurodesis for malignant effusions. Ann Intern Med. 1994;120:56–64
  9. Sahn SA. Malignant pleural effusions. Clin Chest Med. 1985;6:113–117
  10. Kinoshita T, Miyoshi S, Katoh M, et al. Intrapleural administration of a large amount of diluted fibrin glue for intractable pneumothorax. Chest. 2000;117:790–795
  11. Teixeira LR, Wu W, Chang DS, Light RW. The effect of corticosteroids on pleurodesis induced by doxycycline in rabbits. Chest. 1998;114:563–568
  12. Kennedy L, Sahn SA. Talc pleurodesis for the treatment of pneumothorax and pleural effusion. Chest. 1994;106:1215–1222
  13. Xie C, McGovern JP, Wenchao W, Wang N, Light RW. Comparisons of pleurodesis induced by talc with or without thymol iodide in rabbits. Chest. 1998;113:795–799
  14. Werebe EC, Pazetti R, Milanez JRC, Fernandez PP, Capelozzi VL, Jatene FB. Systemic distribution of talc after intrapleural administration in rats. Chest. 1999;115:190–193

PII: S0149-7944(06)00129-2

doi: 10.1016/j.cursur.2006.07.006

Journal of Surgical Education
Volume 64, Issue 1 , Pages 41-45 , January 2007

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